Sunday, March 31, 2013

Kenyan Supreme Court upholds election result

A supporter of losing presidential candidate Raila Odinga gestures as he protests with others in the rain in front of riot police guarding the Supreme Court in Nairobi, Kenya Saturday, March 30, 2013. Kenya's Supreme Court on Saturday upheld the election of Uhuru Kenyatta as the country's next president, in a verdict on a petition by candidate Raila Odinga appealing the election result, ending an election season that riveted the nation amid fears of a repeat of the 2007-08 postelection violence. (AP Photo/Ben Curtis)

A supporter of losing presidential candidate Raila Odinga gestures as he protests with others in the rain in front of riot police guarding the Supreme Court in Nairobi, Kenya Saturday, March 30, 2013. Kenya's Supreme Court on Saturday upheld the election of Uhuru Kenyatta as the country's next president, in a verdict on a petition by candidate Raila Odinga appealing the election result, ending an election season that riveted the nation amid fears of a repeat of the 2007-08 postelection violence. (AP Photo/Ben Curtis)

Kenyan police with clubs chase a small group of supporters of presidential candidate Raila Odinga after they ran down a street smashing shop windows in protest at the verdict of the Supreme Court in Nairobi, Kenya Saturday, March 30, 2013. Kenya's Supreme Court on Saturday upheld the election of Uhuru Kenyatta as the country's next president, in a verdict on a petition by candidate Raila Odinga appealing the election result, ending an election season that riveted the nation amid fears of a repeat of the 2007-08 postelection violence. (AP Photo/Ben Curtis)

Supporters of losing presidential candidate Raila Odinga hold posters designed as banknotes with his face on, as they protest the verdict of the Supreme Court in Nairobi, Kenya, Saturday, March 30, 2013. Kenya's Supreme Court on Saturday upheld the election of Uhuru Kenyatta as the country's next president, in a verdict on a petition by candidate Raila Odinga appealing the election result, ending an election season that riveted the nation amid fears of a repeat of the 2007-08 postelection violence. (AP Photo/Ben Curtis)

FILE - In this Saturday, March 9, 2013 file photo, Kenya's president-elect Uhuru Kenyatta waves at supporters after winning the elections in Nairobi, Kenya. Kenya's Supreme Court on Saturday, March 30, 2013 upheld the election of Uhuru Kenyatta as the country's next president, in a verdict on a petition by candidate Raila Odinga appealing the election result, ending an election season that riveted the nation amid fears of a repeat of the 2007-08 postelection violence. (AP Photo/Jerome Delay, File)

Losing presidential candidate Raila Odinga speaks to the media as he accepts the Supreme Court ruling upholding the election result, and urges unity amongst Kenyans, at a press conference in Nairobi, Kenya, Saturday, March 30, 2013. Kenya's Supreme Court on Saturday upheld the election of Uhuru Kenyatta as the country's next president, ending an election season that riveted the nation amid fears of a repeat of the 2007-08 postelection violence. (AP Photo/Khalil Senosi)

NAIROBI, Kenya (AP) ? Kenya's Supreme Court on Saturday upheld the election of Uhuru Kenyatta as the country's next president and the loser accepted that verdict, ending an election season that riveted the nation with fears of a repeat of the 2007-08 postelection violence.

Jubilant Kenyatta supporters flooded the streets of downtown Nairobi, honking horns, blowing plastic noisemakers and chanting.

But supporters of defeated Prime Minister Raila Odinga angrily protested after the verdict and police fired tear gas at them outside the Supreme Court as well as in the lakeside city of Kisumu, Odinga's hometown.

Two young men participating in riots were fatally shot in Kisumu, police spokesman Masoud Mwinyi told The Associated Press, although it was not clear by whom, and residents there said they could hear gunshots late in the night.

Outbreaks of violence by Odinga supporters were also reported in some Nairobi slums and truckloads of police were called in to quell the demonstrations, according to reports on a police radio heard by an Associated Press reporter.

In a victory speech late Saturday, Kenyatta urged Kenyans to move past the election and pledged to "work with, and serve, all Kenyans without discrimination whatsoever."

"Above all, let us continue to pray for peace in our country," he said.

Odinga, who had challenged the election results, accepted the court ruling and urged national unity and peace.

"It is our view that this court process is another long road in our march toward democracy, for which we have long fought," he said. "The future of Kenya is bright. Let us not allow elections to divide us."

However, Odinga said it was unfortunate that some of his legal team's evidence had been disallowed by the court. This, he said after the court's verdict, means that "in the end Kenyans lost the right to know what indeed happened" in the counting of votes.

"Although we may not agree with some of its findings, and despite all the anomalies we have pointed out, our belief in constitutionalism remains supreme," he said. "Casting doubt on the judgment of the court could lead to higher political and economic uncertainty, and make it more difficult for our country to move forward."

Odinga wished Kenyatta success and said he hopes the incoming government "will have fidelity to our constitution, and implement it to the letter for the betterment of our people."

Saturday's Supreme Court verdict ? following a drawn-out court case that raised tensions across the nation ? means that Kenyatta, the son of Kenya's first president, is to be sworn in as president on April 9. He will become the second sitting president in Africa to face charges at the International Criminal Court.

Kenyatta and Deputy President-elect William Ruto both face charges that they helped orchestrate the 2007-08 postelection violence in which more than 1,000 people died. Both deny the charges. Ruto's trial is set to begin in late May; Kenyatta's is to start in July. Kenyatta has promised to report to The Hague.

Kenyatta's win may complicate the U.S. relationship with Kenya, which has the largest American embassy in Africa. Because of the ICC charges against Kenyatta, the U.S, Britain and other European countries have said they may have limited contact with Kenya's new president.

But Western powers can't completely sever the relationship. Kenya is a key component in the fight against the al-Qaida-linked Somali militant group al-Shabab. Additionally, as East Africa's largest economy, China is strongly courting Kenya's leaders, and the West will be loath to lose economic influence here.

The office of British Prime Minister David Cameron, whose government did not congratulate Kenyatta by name after he was declared the winner, said in a statement that Cameron wrote to Kenyatta on Saturday to note "his strong commitment to the partnership that exists between Kenya and the U.K." The statement said "the Kenyan people had made their sovereign choice" in electing Kenyatta.

The White House congratulated Kenyatta in a statement, which urged Kenyans "to peacefully accept the results of the election."

Lawyers for Odinga, the loser in Kenya's last two elections, had argued before the Supreme Court that the election was marred by irregularities and that Kenyatta did not win enough votes to avoid a runoff election. According to official results, Kenyatta won 50.07 percent of the vote, narrowly avoiding a runoff election against Odinga, who said his case before the Supreme Court would put Kenya's democracy on trial.

But the Supreme Court's unanimous decision, read out by Chief Justice Willy Mutunga, said the election was "conducted in compliance with the constitution and the law" and that Kenyatta and Ruto were legally elected.

"It is the decision of the court that (Kenyatta and Ruto) were validly elected," the ruling said. The reasons behind the judges' decision were not given Saturday. The chief justice said a detailed judgment would be delivered within two weeks.

Unlike after the 2007 election, which degenerated into tribe-on-tribe violence that damaged Kenya's reputation as a stable country, this time Odinga said he had faith in the judiciary's ability to give him a fair hearing.

The court's ruling ended days of anxiety since March 9, when Kenyatta was declared the winner of the March 4 vote that many described as the most complex in Kenya's history. More than 12 million Kenyans participated in the election. Some observers had expected a low registration of voters because of apathy following the 2007-08 violence, but campaigns by Kenyatta, Odinga and other presidential candidates led to the highest registration in the country ever. Kenya's electoral commission registered 14.3 million people.

Election day, though, did not go as planned. An electronic voter ID system intended to prevent fraud failed for reasons yet to be explained by the electoral commission. Vote officials instead used manual voter rolls.

After the polls closed, results were to be sent electronically to Nairobi, where officials would quickly tabulate a preliminary vote count in order to maximize transparency after rigging accusations following the 2007 vote. But that system failed, too. Election officials have indicated that computer servers were overloaded but have yet to fully explain the problem.

As the early count system was still being used, election results showed more than 330,000 rejected ballots, an unusually high number. But after the count resumed with the arrival in Nairobi of manual tallies, the number of rejected ballots was greatly reduced, and the election commission said the computer was mistakenly multiplying the number of rejected ballots by a factor of eight.

Odinga's lawyers told the Supreme Court this week that the switch from electronic voter identification to manual voter roll was contrived to allow inflation of Kenyatta's votes to take him past the 50 percent threshold. That accusation was vehemently denied by the electoral commission and Kenyatta's legal team.

___

Associated Press reporters Rodney Muhumuza in Kampala, Uganda, and Jason Straziuso in Mombasa, Kenya, contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-03-30-AF-Kenya-Election/id-bd43b42566b34beaa18fdf0cb19b27cc

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South African official: Mandela better from pneumonia

JOHANNESBURG (AP) ? A South African official says Nelson Mandela is breathing "without difficulty" after having a procedure to clear fluid in his lung area that was caused by pneumonia.

South African presidential spokesman Mac Maharaj said Saturday that 94-year-old Mandela that the fluid had been "tapped," allowing the former president to breathe more easily.

Maharaj described the fluid problem as a "pleural effusion."

He said Mandela is suffering from pneumonia, using a different term for his ailment. Officials have previously said Mandela, who was taken to a hospital on Wednesday night, has a recurring lung infection.

Source: http://news.yahoo.com/safrican-official-mandela-better-pneumonia-122925761.html

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Navy SEAL accident Ariz.: Member of SEAL Team 6 killed

Navy SEAL accident Ariz.:?Brett Shadle, a special warfare operator chief with the Navy's elite SEAL Team 6 died Thursday when he and another SEAL collided in midair during a parachute training exercise.?

By Associated Press / March 30, 2013

The US Army Golden Knights parachute in before a baseball game between the St. Louis Cardinals and the Colorado Rockies, in St. Louis in July 2012. On Thursday a member of the Navy's SEAL Team 6 died during a parachuting training exercise.

Tom Gannam/AP/File

Enlarge

Brett D. Shadle always had wanted to be a member of the Navy's most elite special forces unit. A year after enlisting, he made it happen and went on to become a highly decorated member of the Navy's famed SEAL Team 6.

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US military officials confirmed Saturday that Shadle, a 31-year-old special warfare operator chief, died Thursday when he and another SEAL collided in midair during a parachute training exercise over the rugged desert of southern Arizona.

Shadle was taken to University of Arizona Medical Center in Tucson, where he was pronounced dead. The other SEAL ? an unidentified E-6 petty officer first class ? remained in stable condition Saturday at the Tucson hospital.

Military officials said the accident was under investigation.

Family members said Shadle, of Elizabethville, Pa., was stationed in Virginia. He was married and had a 2-year-old son and 4-year-old daughter.

His uncle Donald Shadle, 67, of Elizabethville, expressed disbelief, saying his nephew had been on many overseas missions only to come back and get killed during a training exercise.

"He was always a good kid, and he always wanted to be a Navy SEAL and that's what he did," Donald Shadle said.

Shadle enlisted in the Navy in July 2000. The following year he completed his SEAL training and was assigned to his first unit in early 2002.

Navy officials said Shadle had earned multiple Bronze Star Medals with Valor and several service ribbons. While details about his deployments were secret, officials confirmed he had served in Afghanistan and Iraq.

Shadle and a fellow SEAL were practicing "routine military free-fall training" when the accident occurred Thursday afternoon, said US Special Operations Command spokesman Kenneth McGraw. The SEALs collided in midair and landed in separate areas.

The command has a parachute testing and training facility at the Pinal Airpark northeast of Tucson, McGraw said. Training programs are operated there year-round.

The Navy's SEAL Team 6 gained international attention when it was revealed that members of the top secret unit had carried out a raid in Pakistan in 2011 in which Osama bin Laden was killed. Bin Laden became the most wanted man in the world after the Sept. 11, 2001, terrorist attacks that killed almost 3,000 people.

Team 6 was hit hard later that same year when 22 SEALs from the special unit were killed when the helicopter they were riding in was apparently hit by an insurgent's rocket-propelled grenade. None of those killed on the helicopter was part of the bin Laden raid. Their deaths marked the nation's single deadliest day of the decade-long war in Afghanistan.

Associated Press writers Susan Montoya Bryan in Albuquerque, N.M., and Ron Todt in Philadelphia contributed to this report.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/G_7pQ_6pg9A/Navy-SEAL-accident-Ariz.-Member-of-SEAL-Team-6-killed

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PFT: Raiders close to Flynn trade, cutting Palmer

Troy PolamaluAP

Sometimes, wishes are quickly granted.? Sometimes, they already were.

Steelers safety Troy Polamalu wants player input in rule changes.? But the players already have input.

?I do wish . . . that the NFL did have a voice from the players? side, whether it?s our players? union president, or team captains, or our executive committee on the players? side,? Polamalu said earlier today on ESPN.? ?Because we?re the guys that realize the risk, we?re the guys on the field.?

As MDS pointed out, the players have a voice in the rule-revising process.? Specifically, this year?s the rule changes were discussed with NFLPA president Domonique Foxworth, who worked with Lester Archambeaux, Charlie Batch, Ernie Conwell, Matt Hasselbeck, Brandon Moore, Jeff Saturday, Ben Watson, and Eric Winston in providing input to the Competition Committee.

Also, Will Montgomery of the Redskins presented video to the Competition Committee in connection with the rule that makes the snapper a defenseless player.

Former players also had a voice with the Player Safety Advisory panel, which includes John Madden, Ronnie Lott, Ernie Accorsi, Antonio Freeman, Patrick Kerney, Willie Lanier, Oliver Luck, Steve Mariucci, Anthony Munoz.

So, basically, Polamalu already got what he wanted, without finding a lamp or losing an eyelash.

Source: http://profootballtalk.nbcsports.com/2013/03/29/raiders-appear-close-to-adding-matt-flynn-cutting-carson-palmer/related/

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Saturday, March 30, 2013

Abbyy FineReader Touch


Businesses have been making increasing use of smart phones and tablets as work tools. Thanks to Abbyy FineReader Touch, remote workers can use iPhones and iPads to snap images of documents and upload them to Abby's cloud-based FineReader Online service to save it in various searchable, editable formats. Though it's no substitute for a desktop optical character recognition (OCR) program, this iOS app does let you scan and convert documents from anywhere, which is very handy.

Abbyy is a provider of OCR, PDF, and document conversion software, including the Editors' Choice FineReader 11, as well as older versions (FineReader 6 and 9) that are frequently bundled with the scanners we test. Though those solutions are for the desktop, Abbyy also offers mobile apps, including Abbyy FineReader Touch.

The FineReader Touch Interface
The app's iPhone interface is a black screen with toolbars on the top and bottom. Once you've scanned documents, a list of them, giving the date and time of the scan, file name and type, length of time available on the server for each document, appears in the center of the screen. The button at top left gives you the status of the document you're scanning. At top right is a search button (though it searches on documents, not text).

The tab at top center shows the balance of document conversions you have available to you. (You start with 100). Touching the tab takes you to the store, where you can buy more: $2.99 for 20 pages, $4.99 for 50 pages, $6.99 for 100 pages, and $9.99 for 200 pages.

At bottom left is an information tab, which provides Help, lets you email Abby for support; lets you rate the app, and tells you about other Abbyy apps. At bottom right, the gear icon lets you change settings. At bottom center, the camera icon lets you image a document with your iPhone's camera.

From the FineReader Online site, you can also upload saved documents for conversion to Word, Excel, PDF, PDF/A, RTF, TXT, and OpenDocument Text formats. You can access the documents you've converted, open and save them, or export them to Google Docs, Evernote, or Dropbox. After 14 days, your documents will be automatically deleted from the FineReader site.

Testing
I used my iPhone 5 to image text pages (printed from Word documents), tables, magazine pages, and other documents in FineReader Touch, and save them in appropriate formats (Word .docx is default). Text recognition of one-page documents scanned to Word format took an average of 44 seconds per page. That's much slower than typical desktop-based OCR speeds, but keep in mind that you're not likely to be using FineReader Touch to scan documents en masse.

OCR results were generally good. FineReader could recognize text down to 6 pt on our standard Times New Roman and Arial test pages in documents imaged in good lighting. The FineReader cloud also did a good job in converting most of the saved documents I sent to it, though occasionally a document with unusual formatting would stump it.

Abbyy FineReader Touch is optimized for the iPhone 5, but it also works with the iPhone 4 and 4S, as well as recent iPods touch, and all iPads except for the first-generation model. Though although the app is compatible with the iPad 2, I wasn't surprised that OCR performance was abysmal, given the device's primitive 0.9-megapixel camera. It undoubtedly would have done better with the 3- and 5-megapixel cameras of the most recent two iPads (and the iPad mini's 5-megapixel camera). Even with the iPhone 5, lighting and document/camera positioning had some effect on scan quality.

Abbyy FineReader Touch has its limitations. It's most accurate with recent iPhones and iPads with higher-resolution cameras, and shooting for OCR requires good lighting, and some care in positioning the documents. Many portable scanners already come with OCR software, are faster, and working through the cloud may be an extra step if you're scanning and converting a series of documents to your hard drive. As a paid service, its costs could add up if you scan a lot of documents. Documents handled through the FineReader cloud are given generic names based on the date and the number of documents uploaded to FineReader (by all users) on that date, so you'll have to go back and change them to a more usable name.

However, these quibbles shouldn't detract from its usefulness to people who may need to make quick scans of documents to readable text while in the field: scholars, researchers?secret agents, for that matter. For them, ABBYY FineReader Touch may be the best solution for their mobile scanning needs.

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/w1FBd2hXDrQ/0,2817,2417192,00.asp

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Twitter Link Roundup #172 ? Small Business, Startups, Innovation ...

internet

Every day on the crowdSPRING Twitter account and on my own Twitter account, I post links to posts or videos I enjoyed reading or viewing. These posts and videos are about logo design, web design, startups, entrepreneurship, small business, leadership, social media, marketing, and more! Here are some of the links that I?ve liked and shared this past week!

The image above shows a map of the Internet, created by an anonymous researcher, who hacked hundreds of thousands of computers around the world in order to create the map. You can find the full article in the Other section below, including an animated version of this map, showing where people are logging-in throughout the day, and changes in traffic patterns over time.

Empower Your Small Business ? NEW edition: marketing, lean business, paid search, #1 mistake ? http://crowdspring.co/15Qb2bj

Marketing and Selling to Squirrels (tips on how to deal with people?s short attention spans online) ? http://crowdspring.co/10dKilc

Lean Business: Freelancers for ALL My Friends! ? http://crowdspring.co/10EOryR

Lead Or Follow, But Keep Your Eyes On The Crowd ? http://crowdspring.co/YcD1C6

Invest in Your Customers More Than Your Brand | Michael Schrage-Harvard Business Review ? http://crowdspring.co/YipU2f

Lessons Learned from Bill Gross? 35 IPOs/Exits and 40 Failures ? http://crowdspring.co/10oLgLv

Scaling Teams and the Fight Against Human Nature | Rand?s Blog ? http://crowdspring.co/YhtHgi

3 Things I Did Wrong with My Last Startup ? http://crowdspring.co/15N4i0q

Lean Business: Freelancers for ALL My Friends! ? http://crowdspring.co/10EOryR

Six Tips to Building a World-Class Team ? http://crowdspring.co/10sidH7

A scientific guide to saying ?no?: How to avoid temptation and distraction | Buffer Blog ? http://crowdspring.co/YiD2oi

When Things Don?t Work Out | by Fred Wilson ? http://crowdspring.co/11TPkCS

Is Equity Crowdfunding A Threat To Venture Capitalists? | TechCrunch ? http://crowdspring.co/11rp1DR

Invest in Your Customers More Than Your Brand | Michael Schrage-Harvard Business Review ? http://crowdspring.co/YipU2f

Investment Crowdfunding is A Ghetto Stock Market | Forbes ? http://crowdspring.co/11lV7kc

Lead Or Follow, But Keep Your Eyes On The Crowd ? http://crowdspring.co/YcD1C6

How Groupthink Can Ruin Startups | The Next Web ? http://crowdspring.co/11Em8j2

Einstein?s Problem-Solving Formula, And Why You?re Doing It All Wrong ? http://crowdspring.co/YisA02

Revenue Traction Doesn?t Mean Product Market Fit ? http://crowdspring.co/YbdwkI

Forecasting Fox | NYTimes ? http://crowdspring.co/10um8mH

How closely knit design and engineering teams put Pinterest on a rocket ship | Gigaom ? http://crowdspring.co/YebZKB

True To Its Roots: Why Kickstarter Won?t Sell | Fast Company ? http://crowdspring.co/Ybdb1s

Good insight about collaboration, usability and design ? An interview with Joshua Porter | Inside Intercom ? http://crowdspring.co/11ElEJy

Tech Startup City: G2 Crowd in Chicago | Forbes ? http://crowdspring.co/15Z0XJ0

Getting A Head Start On Five Factors Reshaping E-Commerce | Enterprise Irregulars ? http://crowdspring.co/10G2i7Z

How to stay happy at a startup | VentureBeat ? http://crowdspring.co/10EWknX

Why Organizations Are So Afraid to Simplify ? Ron Ashkenas-Harvard Business Review http://crowdspring.co/10uqQAO

The most persuasive words in English: The psychology of language | Buffer Blog ? http://crowdspring.co/11lSBuq

Chartbeat Demonstrates Below-the-Fold Ad Placement Is More Valuable Than Originally Assumed ? http://crowdspring.co/11lRxGX

What Agencies Want From Twitter | Digiday ? http://crowdspring.co/YdjZeQ

Half of What Online Advertisers Know About You Is Wrong ? http://crowdspring.co/11po4f8

Amazon?s New Mobile Ad Network Is A Huge Threat To Google | Business Insider ? http://crowdspring.co/YeaR9V

How Opting People OUT Can Actually Improve Your Email Marketing | Hubspot ? http://crowdspring.co/11rqY39

UX Myths That Hurt SEO ? Whiteboard Friday | SEOmoz ? http://crowdspring.co/10uky4j

Invest in Your Customers More Than Your Brand | Michael Schrage-Harvard Business Review ? http://crowdspring.co/YipU2f

Is Your Meta Description Working As Hard As Your Tagline? | Rival IQ ? http://crowdspring.co/11CrAmA

Native Advertising Is Bad News | Digiday (by Ben Kunz) ? http://crowdspring.co/10skEJD

15 Steps to the Ultimate Lead Capture Landing Page | Unbounce ? http://crowdspring.co/11rrMoD

40 Creative Sport Inspired Print Ads ? http://crowdspring.co/YasBD5

Store Combats Showrooming With $5 ?Just Looking? Fee | Consumerist ? http://crowdspring.co/11Ke7cf

40 Brilliant Business card design examples for your inspiration | Webneel ? http://crowdspring.co/10F4AEz

25 Amazing Photoshop Color Effect Tutorials ? http://crowdspring.co/Zn9Urj

35 Fresh Examples of Corporate Business Cards ? http://crowdspring.co/Yapnj3

A Collection of Stunningly Detailed App Icons | UnderWorld Magazines ? http://crowdspring.co/YarV0l

Top 5 Free Tools To Create Amazing Infographics ? http://crowdspring.co/11Cy8S6

20 Useful Examples of Cardboard Texture ? http://crowdspring.co/ZnaS6X

15+ Cyrillic Fonts for Free Download ? http://crowdspring.co/ZndEJn

20+ New Brochure Design Examples | Top Design Magazine ? http://crowdspring.co/ZndhP3

Flat Design VS Metro UI Trend Examples ? http://crowdspring.co/YasaIZ

50 Free Abstract photoshop Brushes | Levelgraphic ? http://crowdspring.co/ZndB04

10 Good Tips for Creating Effective Brochure Designs ? http://crowdspring.co/OAK8vB

25 Beautiful Examples Of iOS App Splash Screens ? http://crowdspring.co/Yaqtes

Perspective in Illustrator: Multiple Objects | Creative Beacon ? http://crowdspring.co/Zndv8Q

45 Incredible Examples of Food Art | InstantShift ? http://crowdspring.co/ZnaJAw

Creative Presentation Folder Designs with Unique Brand Character ? http://crowdspring.co/ZndG4a

10 Design Tutorials You Don?t Want To Miss | Inspired Magazine ? http://crowdspring.co/Znd66e

15+ beautiful blog designs | Webdesigner Depot ? http://crowdspring.co/Yaqi2M

9 Vintage and Retro Billboard Designs ? http://crowdspring.co/YarVO5

15 Impressive Photoshop Text Effect Tutorials | Silky Designs ? http://crowdspring.co/Zneiqq

40+ Cool and Useful Ice Textures For Free | Naldz Graphics ? http://crowdspring.co/Znelm7

Best Examples of Skeuomorph Design ? http://crowdspring.co/ZnaNQG

40 Creative Sport Inspired Print Ads ? http://crowdspring.co/YasBD5

25 Old School and Retro Free Fonts ? http://crowdspring.co/ZnaFAB

20 Flat Style Business Card Examples ? http://crowdspring.co/YapH17

10 Inspiring iPhone weather UI ? http://crowdspring.co/YapqLM

Photoshop Tutorials ? Improve Typography Skills with Text Effect Tutorials?Tutorials | Graphic Design Junction ? http://crowdspring.co/YapdrV

20 Great fonts you should have in your collection. | Design Reviver ? http://crowdspring.co/Zna4Py

Legal Contracts for Software Developers Who Hate Contracts (w/free contract template to use today) ? http://bit.ly/1ySfi

Legal Contracts for Graphic Designers Who Hate Contracts (w/free contract template to use today) ? http://bit.ly/XTLkS

20 Great fonts you should have in your collection. | Design Reviver ? http://crowdspring.co/Zna4Py

40 of chosen logo design tutorials ? http://crowdspring.co/Yaq3oy

15+ Cyrillic Fonts for Free Download ? http://crowdspring.co/ZndEJn

40 Creative Electrical Themed Logo Design examples for your inspiration ? http://crowdspring.co/YashnW

25 Old School and Retro Free Fonts ? http://crowdspring.co/ZnaFAB

25+ Futuristic Logos | iBrandStudio ? http://crowdspring.co/Yaqy1X

15 Steps to the Ultimate Lead Capture Landing Page | Unbounce ? http://crowdspring.co/11rrMoD

How to Use Pattern in Web and Mobile for Better UX ? Design for User Experience ? http://crowdspring.co/ZndrG5

40 Inspirational Websites Powered By HTML5 ? http://crowdspring.co/Yapjjl

25 diverse patterns in site design | Webdesigner Depot ? http://crowdspring.co/ZncZHO

10+ Data Visualization Tutorials [jQuery and HTML/CSS] | gonzoblog ? http://crowdspring.co/Yasl7a

A Collection of Stunningly Detailed App Icons | UnderWorld Magazines ? http://crowdspring.co/YarV0l

20+ Inspirational Orange Color Websites Designs ? http://crowdspring.co/ZndPo4

25 diverse patterns in site design | Webdesigner Depot ? http://crowdspring.co/ZncZHO

10 Useful & Fresh jQuery Plugins | Graphic Design Junction ? http://crowdspring.co/Yaqz5P

20+ Examples of Effective Call-to-Action Buttons ? http://crowdspring.co/Znegii

The Ultimate UX Design of Form Validation | Designmodo ? http://crowdspring.co/Znbfi1

A Look At Photography Website Design ? 26 Interesting Examples ? http://crowdspring.co/ZnaYM1

Responsive Web Design With Physical Units | Smashing Mobile ? http://crowdspring.co/Yaq8Zi

This Is the Most Detailed Picture of the Internet Ever (and Making it Was Very Illegal) ? http://crowdspring.co/11lSgb5

How to Write Interesting Content for a ?Boring? Topic | Copyblogger ? http://crowdspring.co/YapDP0

Why the Rich Don?t Give to Charity | Ken Stern-The Atlantic ? http://crowdspring.co/10sgtNX

Thomas Edison, Power-Napper: The Great Inventor on Sleep and Success | Brain Pickings ? http://crowdspring.co/11rqnyf

Why Ron Johnson Is Struggling at J. C. Penney | The New Yorker ? http://crowdspring.co/10siWIm

25 Things You?ll Have to Explain to Your Kids About Marketing One Day | Hubspot ? http://crowdspring.co/11rtJBr

The Complicated Legacy of Boris Berezovsky-Why 1 man was both the Stalin & Trotsky of our time ? http://crowdspring.co/ZsK8pa

Interesting look at the benefits & costs of delayed marriage in U.S. (average age people marry is increasing) ? http://crowdspring.co/10uiYiG

I hope you enjoy these links! Please leave a comment and let me know what you liked/didn?t like.

Source: http://blog.crowdspring.com/2013/03/twitter-link-roundup-172-small-business-social-media-design-startups-innovation-marketing-and-more/

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Friday, March 29, 2013

N. Ireland struggles to confront Catholic Church?s enslavement of 1000s of women (Americablog)

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OK to cut returning veteran's job if decision wasn't based on military ...

Generally, members of the military released from active duty service are entitled to return to their former jobs.

The ?Uni?formed Ser??vices Employ-ment and Re??em??ploy??ment Rights Act (USERRA) states that the returning service members shall be re-employed ?in the position of em??ployment in which the person would have been employed if the continuous em??ployment of such person with the employer had not been interrupted by such service.?

But what happens if bad economic times force a layoff before the em??ployee returns to work? Is he exempt from the cuts? Not according to the 8th Circuit Court of Appeals.

Recent case: Douglas worked as a maintenance technician before being called to active military duty. He left the service early after he had an ad?verse reaction to a vaccine. He wanted to report back to his job. But while Douglas had been deployed, the employer underwent two reductions in force after failing to make a profit.

The second round of layoffs affected Douglas? department and was based on job duties, skills and other factors. On the day he returned to work, Douglas was informed that his job had been cut.

He sued, alleging he was entitled to return to his job even in the face of a reduction in force.

The court disagreed. It pointed out that USERRA?s language indicates that service members don?t get to keep their jobs if a position was eliminated for nondiscriminatory reasons while they were on active duty. (Millhauser v. Minco, No. 12-1756, 8th Cir., 2012)

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Penn researchers show stem cell fate depends on 'grip'

Penn researchers show stem cell fate depends on 'grip' [ Back to EurekAlert! ] Public release date: 28-Mar-2013
[ | E-mail | Share Share ]

Contact: Evan Lerner
elerner@upenn.edu
215-573-6604
University of Pennsylvania

The field of regenerative medicine holds great promise, propelled by greater understanding of how stem cells differentiate themselves into many of the body's different cell types. But clinical applications in the field have been slow to materialize, partially owing to difficulties in replicating the conditions these cells naturally experience.

A team of researchers from the University of Pennsylvania has generated new insight on how a stem cell's environment influences what type of cell a stem cell will become. They have shown that whether human mesenchymal stem cells turn into fat or bone cells depends partially on how well they can "grip" the material they are growing in.

The research was conducted by graduate student Sudhir Khetan and associate professor Jason Burdick, along with professor Christopher Chen, all of the School of Engineering and Applied Science's Department of Bioengineering. Others involved in the study include Murat Guvendiren, Wesley Legant and Daniel Cohen.

Their study was published in the journal Nature Materials.

Much research has been done on how stem cells grow on two-dimensional substrates, but comparatively little work has been done in three dimensions. Three-dimensional environments, or matrices, for stems cells have mostly been treated as simple scaffolding, rather than as a signal that influences the cells' development.

Burdick and his colleagues were interested in how these three-dimensional matrices impact mechanotransduction, which is how the cell takes information about its physical environment and translates that to chemical signaling.

"We're trying to understand how material signals can dictate stem cell response," Burdick said. "Rather than considering the material as an inert structure, it's really guiding stem cell fate and differentiation what kind of cells they will turn into."

The mesenchymal stem cells the researchers studied are found in bone marrow and can develop into several cell types: osteoblasts, which are found in bone; chondrocytes, which are found in cartilage; and adipocytes, which are found in fat.

The researchers cultured them in water-swollen polymer networks known as hydrogels, which share some similarities with the environments stem cells naturally grow in. These materials are generally soft and flexible contact lenses, for example, are a type of hydrogel but can vary in density and stiffness depending on the type and quantity of the bonds between the polymers. In this case, the researchers used covalently cross-linked gels, which contain irreversible chemical bonds.

When seeded on top of two-dimensional covalently cross-linked gels, mesenchymal stem cells spread and pulled on the material differently depending on how stiff it was. Critically, the mechanics guide cell fate, or the type of cells they differentiate it into. A softer environment would produce more fat-like cells and a stiffer environment, where the cells can pull on the gel harder, would produce more bone-like cells.

However, when the researchers put mesenchymal stem cells inside three-dimensional hydrogels of varying stiffness, they didn't see these kinds of changes.

"In most covalently cross-linked gels, the cells can't spread into the matrix because they can't degrade the bonds they all become fat cells," Burdick said. "That tells us that in 3D covalent gels the cells don't translate the mechanical information the same way they do in a 2D system."

To test this, the researchers changed the chemistry of their hydrogels so that the polymer chains were connected by a peptide that the cells could naturally degrade. They hypothesized that, as the cells spread, they would be able to get a better grip on their surrounding environment and thus be more likely to turn into bone-like cells.

In order to determine how well the cells were pulling on their environment, the researchers used a technique developed by Chen's lab called 3D traction force microscopy. This technique involves seeding the gel with microscopic beads, then tracking their location before and after a cell is removed.

"Because the gel is elastic and will relax back into its original position when you remove the cells," Chen said, "you can quantify how much the cells are pulling on the gel based on how much and which way it springs back after the cell is removed."

The results showed that the stem cells' differentiation into bone-like cells was aided by their ability to better anchor themselves into the growth environment.

"With our original experiment, we observed that the cells essentially didn't pull on the gel. They adhered to it and were viable, but we did not see bead displacement. They couldn't get a grip," Burdick said. "When we put the cells into a gel where they could degrade the bonds, we saw them spread into the matrix and deform it, displacing the beads."

As an additional test, the researchers synthesized another hydrogel. This one had the same covalent bonds that the stem cells could naturally degrade and spread through but also another type of bond that could form when exposed to light. They let the stem cells spread as before, but at the point the cells would begin to differentiate about a week after they were first encapsulated the researchers further "set" the gel by exposing it to light, forming new bonds the cells couldn't degrade.

"When we introduced these cross-links so they could no longer degrade the matrix, we saw an increase toward fat-like cells, even after letting them spread," Burdick said. "This further supports the idea that continuous degradation is needed for the cells to sense the material properties of their environment and transduce that into differentiation signals."

Burdick and his colleagues see these results as helping develop a better fundamental understanding of how to engineer tissues using stem cells.

"This is a model system for showing how the microenvironment can influence the fate of the cells," Burdick said.

###

The research was supported by the National Science Foundation, the National Institutes of Health and the David and Lucile Packard Foundation.

Sudhir Khetan is now an assistant professor of bioengineering at Union College.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Penn researchers show stem cell fate depends on 'grip' [ Back to EurekAlert! ] Public release date: 28-Mar-2013
[ | E-mail | Share Share ]

Contact: Evan Lerner
elerner@upenn.edu
215-573-6604
University of Pennsylvania

The field of regenerative medicine holds great promise, propelled by greater understanding of how stem cells differentiate themselves into many of the body's different cell types. But clinical applications in the field have been slow to materialize, partially owing to difficulties in replicating the conditions these cells naturally experience.

A team of researchers from the University of Pennsylvania has generated new insight on how a stem cell's environment influences what type of cell a stem cell will become. They have shown that whether human mesenchymal stem cells turn into fat or bone cells depends partially on how well they can "grip" the material they are growing in.

The research was conducted by graduate student Sudhir Khetan and associate professor Jason Burdick, along with professor Christopher Chen, all of the School of Engineering and Applied Science's Department of Bioengineering. Others involved in the study include Murat Guvendiren, Wesley Legant and Daniel Cohen.

Their study was published in the journal Nature Materials.

Much research has been done on how stem cells grow on two-dimensional substrates, but comparatively little work has been done in three dimensions. Three-dimensional environments, or matrices, for stems cells have mostly been treated as simple scaffolding, rather than as a signal that influences the cells' development.

Burdick and his colleagues were interested in how these three-dimensional matrices impact mechanotransduction, which is how the cell takes information about its physical environment and translates that to chemical signaling.

"We're trying to understand how material signals can dictate stem cell response," Burdick said. "Rather than considering the material as an inert structure, it's really guiding stem cell fate and differentiation what kind of cells they will turn into."

The mesenchymal stem cells the researchers studied are found in bone marrow and can develop into several cell types: osteoblasts, which are found in bone; chondrocytes, which are found in cartilage; and adipocytes, which are found in fat.

The researchers cultured them in water-swollen polymer networks known as hydrogels, which share some similarities with the environments stem cells naturally grow in. These materials are generally soft and flexible contact lenses, for example, are a type of hydrogel but can vary in density and stiffness depending on the type and quantity of the bonds between the polymers. In this case, the researchers used covalently cross-linked gels, which contain irreversible chemical bonds.

When seeded on top of two-dimensional covalently cross-linked gels, mesenchymal stem cells spread and pulled on the material differently depending on how stiff it was. Critically, the mechanics guide cell fate, or the type of cells they differentiate it into. A softer environment would produce more fat-like cells and a stiffer environment, where the cells can pull on the gel harder, would produce more bone-like cells.

However, when the researchers put mesenchymal stem cells inside three-dimensional hydrogels of varying stiffness, they didn't see these kinds of changes.

"In most covalently cross-linked gels, the cells can't spread into the matrix because they can't degrade the bonds they all become fat cells," Burdick said. "That tells us that in 3D covalent gels the cells don't translate the mechanical information the same way they do in a 2D system."

To test this, the researchers changed the chemistry of their hydrogels so that the polymer chains were connected by a peptide that the cells could naturally degrade. They hypothesized that, as the cells spread, they would be able to get a better grip on their surrounding environment and thus be more likely to turn into bone-like cells.

In order to determine how well the cells were pulling on their environment, the researchers used a technique developed by Chen's lab called 3D traction force microscopy. This technique involves seeding the gel with microscopic beads, then tracking their location before and after a cell is removed.

"Because the gel is elastic and will relax back into its original position when you remove the cells," Chen said, "you can quantify how much the cells are pulling on the gel based on how much and which way it springs back after the cell is removed."

The results showed that the stem cells' differentiation into bone-like cells was aided by their ability to better anchor themselves into the growth environment.

"With our original experiment, we observed that the cells essentially didn't pull on the gel. They adhered to it and were viable, but we did not see bead displacement. They couldn't get a grip," Burdick said. "When we put the cells into a gel where they could degrade the bonds, we saw them spread into the matrix and deform it, displacing the beads."

As an additional test, the researchers synthesized another hydrogel. This one had the same covalent bonds that the stem cells could naturally degrade and spread through but also another type of bond that could form when exposed to light. They let the stem cells spread as before, but at the point the cells would begin to differentiate about a week after they were first encapsulated the researchers further "set" the gel by exposing it to light, forming new bonds the cells couldn't degrade.

"When we introduced these cross-links so they could no longer degrade the matrix, we saw an increase toward fat-like cells, even after letting them spread," Burdick said. "This further supports the idea that continuous degradation is needed for the cells to sense the material properties of their environment and transduce that into differentiation signals."

Burdick and his colleagues see these results as helping develop a better fundamental understanding of how to engineer tissues using stem cells.

"This is a model system for showing how the microenvironment can influence the fate of the cells," Burdick said.

###

The research was supported by the National Science Foundation, the National Institutes of Health and the David and Lucile Packard Foundation.

Sudhir Khetan is now an assistant professor of bioengineering at Union College.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-03/uop-h032813.php

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Final Fantasy V arrives on iOS, is unlikely to be the last

Final Fantasy V arrives on iOS, is unlikely to be the last

A touch iteration of the once SNES-bound Final Fantasy V has now appeared on the iTunes App Store, with a softer graphical lick, some new job classes (Gladiator, Cannoneer, Oracle and Necromancer) and an obligatory extra boss to test your leveling-up skills against. The price of four new costumes for your meteor-riding protagonists? Just shy of $16. Saving the world was never going to be cheap easy.

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Comments

Via: Destructoid

Source: Final Fantasy V (iTunes)

Source: http://www.engadget.com/2013/03/28/final-fantasy-v-arrives-on-ios-is-unlikely-to-be-the-last/

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Genetic 'spelling mistakes' that increase risk of common cancers determined

Mar. 27, 2013 ? More than 80 genetic 'spelling mistakes' that can increase the risk of breast, prostate and ovarian cancer have been found in a large, international research study within the framework of the EU network COGS. For the first time, the researchers also have a relatively clear picture of the total number of genetic alterations that can be linked to these cancers. Ultimately the researchers hope to be able to calculate the individual risk of cancer, to better understand how these cancers develop and to be able to generate new treatments.

The main findings are published in five articles in a special issue on genetic risk factors for cancer in the scientific journal Nature Genetics. The articles originate from COGS (Collaborative Oncological Gene-environment Study), an EU-based consortium where more than 160 research groups from all over the world are included. In the five COGS studies 100,000 patients with breast, ovarian or prostate cancer and 100,000 healthy individuals from the general population were included.

The scientists performed genetic analyses on all study participants. The composition of the nitrogen bases A, G, C and T was studied on 200,000 selected sections of the DNA strand. When cancer patients had significantly different compositions compared to healthy control subjects, the differences were considered to be relevant to risk of disease. The alterations can be described as a genetic 'spelling mistake', where A, G, C or T have been replaced with another letter. This spelling mistake is called Single Nucleotide Polymorphism (SNP) -- pronounced 'snip'.

For breast cancer the researchers found 49 genetic typos or SNPs, which is more than double the number previously found. In the case of prostate cancer, researchers have discovered another 26 deviations, which means that a total number of 78 SNPs may be linked to the disease. For ovarian cancer 8 new relevant SNPs were found.

"An equally important finding is that we identified how many additional SNPs that could influence the risk of breast cancer and prostate cancer, respectively. For breast cancer the number is 1,000 and for prostate cancer 2,000," says Per Hall, Professor at Karolinska Institutet and the coordinator of the COGS consortium. "We also have a picture of where in the genome we should look in future studies.

SNPs are part of our natural heritage, we all have them. How it affects the individual depends on where on the DNA strand the genetic deviation is found. The researchers now hope to be able to evaluate the importance of the identified deviations, so that it will be possible to more clearly predict which individuals are at high risk of developing one of these cancers.

"We're now on the verge of being able to use our knowledge to develop tests that could complement breast cancer screening and take us a step closer to having an effective prostate cancer screening programme," says Professor Doug Easton of the University of Cambridge, UK, who has led several of the presented studies.

At the same time as these five articles are published in Nature Genetics, the Nature Publishing Group publishes another two articles on studies emanating from the COGS collaboration in Nature Communications. An additional number of COGS articles will be published simultaneously in other journals. The studies are financed by partly different funders; however the COGS project is mainly funded by the European Commission 7th Framework Programme. Other financial contributors to the COGS project are the M?rit and Hans Rausing Initiative against Breast Cancer, the Swedish Research Council, Cancer Research UK and the Cancer Risk Prediction Center (CRisP).

"COGS is the largest genotyping project in the world targeting identification of genetic alterations that influence the risk of common cancers. The collaborative efforts have been tremendous and key to success," says COGS coordinator Per Hall.

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Story Source:

The above story is reprinted from materials provided by Karolinska Institutet.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal References:

  1. Rosalind A Eeles et al. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nature Genetics, 2013; 45 (4): 385 DOI: 10.1038/ng.2560
  2. Paul D P Pharoah et al. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nature Genetics, 2013; 45 (4): 362 DOI: 10.1038/ng.2564
  3. Stig E Bojesen et al. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nature Genetics, 2013; 45 (4): 371 DOI: 10.1038/ng.2566
  4. Montserrat Garcia-Closas et al. Genome-wide association studies identify four ER negative?specific breast cancer risk loci. Nature Genetics, 2013; 45 (4): 392 DOI: 10.1038/ng.2561
  5. Kyriaki Michailidou et al. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nature Genetics, 2013; 45 (4): 353 DOI: 10.1038/ng.2563

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/SMKCHbFWyCs/130327132552.htm

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Thursday, March 28, 2013

Pfizer lung cancer pill rejected by NICE

Mar 26 (Reuters) - Leading money winners on the 2013 PGATour on Monday (U.S. unless stated): 1. Tiger Woods $3,787,600 2. Brandt Snedeker $2,859,920 3. Matt Kuchar $2,154,500 4. Steve Stricker $1,820,000 5. Phil Mickelson $1,650,260 6. Hunter Mahan $1,553,965 7. John Merrick $1,343,514 8. Dustin Johnson $1,330,507 9. Russell Henley $1,313,280 10. Kevin Streelman $1,310,343 11. Keegan Bradley $1,274,593 12. Charles Howell III $1,256,373 13. Michael Thompson $1,254,669 14. Brian Gay $1,171,721 15. Justin Rose $1,155,550 16. Jason Day $1,115,565 17. Chris Kirk $1,097,053 18. ...

Source: http://news.yahoo.com/pfizer-lung-cancer-pill-rejected-nice-001046387--finance.html

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Wednesday, March 27, 2013

Maybe Isolation, Not Loneliness, Shortens Life

NPR:

Loneliness hurts, but social isolation can kill you. That's the conclusion of a study of more than 6,500 people in the U.K.

The study, by a team at University College London, comes after decades of research showing that both loneliness and infrequent contact with friends and family can, independently, shorten a person's life. The scientists expected to find that the combination of these two risk factors would be especially dangerous.

Read the whole story at NPR

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Source: http://www.huffingtonpost.com/2013/03/26/maybe-isolation-not-lonel_n_2956840.html

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Tuesday, March 26, 2013

Report: Pentagon must do more to stop sex assaults (The Arizona Republic)

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'Walking Dead' shocks with heartbreaking death

By Drusilla Moorhouse, TODAY contributor

As 'The Walking Dead' nears the conclusion of its third season, fans have been bracing for the death of at least one major character. Even so, many of us gasped aloud at the shocking demise of someone we've loved to hate since season one.

You know the drill: spoilers ahead.

Gene Page / AMC

RIP, Merle Dixon. By the standards of the redemption-equals-death TV trope, the villain's fate was sealed the moment he released Michonne. After secretly capturing her -- because he correctly predicted Rick would change his mind about sacrificing her to the Governor to save his group -- Merle had a change of heart.

As "This Sorrowful Life" slowly drifted to its horrifying final scene, a cloud of doom hovered above Daryl's incredibly damaged but increasingly sympathetic brother. Even Glenn, who aside from Michonne had the most reason to hate Merle, seemed to accept him as part of the group -- if not actually forgive him for humiliating his fianc?e.

Gene Page / AMC

With Hershel's blessing, Glenn proposed to Maggie, offering another ray of hope -- like the birth of Judith -- in the midst of so much tragedy and conflict. So what if he didn't buy his ring at Tiffany's? (And the bonus of hacking it off a zombie's finger means his bride also has "something borrowed." Win!)

But the Dixon brothers' bond was the true essence of this season's penultimate episode.

Daryl arrived at the Governor's armistice ambush too late to save Merle from his suicide mission. After setting up as a sniper with an army of walkers to back him up, Merle fired on the Woodbury contingent but was inevitably captured. And of course he was fed to the undead by the man who ordered him to kill 16 innocent people.

When Daryl arrived on the scene, it was too late: the Governor's gang was long gone -- and so was his brother. His discovery Merle devouring one of his victims (first revealed with a closeup of his homemade prosthesis) was both gruesome and heartbreaking.

Gene Page / AMC

At least Merle won't distract the troops -- now declared a democracy by Rick -- when they go to war in next week's finale.

Will you miss Merle? Who else do you think will fall in the finale's bloody battle? Tell us on our Facebook page!

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Source: http://theclicker.today.com/_news/2013/03/25/17457969-walking-dead-shocker-horrifying-heartbreaking-death-and-redemption?lite

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Monday, March 25, 2013

Rebel mortar fire hits Damascus, army gunners retaliate

By Oliver Holmes

BEIRUT (Reuters) - Syrian rebels lobbed mortar rounds into central Damascus on Monday, killing at least two people and drawing a fierce army response as bombardments shook the heart of the capital.

The state news agency said mortar bombs fired by "terrorists" had killed two people and wounded others near the Opera House on Ummayad Square, where Baath Party headquarters, Air Force Intelligence and state television are also located.

The military retaliated with artillery fire from Mount Qasioun, overlooking the city. "I've heard dozens of regime shells so far, pounding rebels," one resident said.

Photos posted by opposition activists showed black smoke rising from the square during what residents said was one of the heaviest bombardments in central Damascus since a revolt against President Bashar al-Assad erupted two years ago.

"The city is under attack," said one bewildered resident, adding that the explosions had begun at 6:30 a.m. (12.30 a.m. EDT).

The conflict in Syria has killed 70,000 people and forced a million to flee the country, the United Nations says. Sustained fighting in Damascus could send thousands more into neighboring states, especially Lebanon, which already hosts 370,000 of them.

There were no immediate reports that the rebels, who have pushed into the Kfar Souseh district, a few hundred meters (yards) from Ummayad Square, were trying to advance further.

Assad's forces have retained control of central Damascus and most other Syrian cities, while losing swathes of territory to insurgents elsewhere, especially in the north and east.

Colonel Riad al-Asaad, founder of the rebel Free Syrian Army (FSA), lost a leg in an overnight blast caused by a bomb placed beneath his car in the opposition-held eastern town of al-Mayadin, his deputy said. A Turkish official said Asaad was now being treated in Turkey and that his life was not in danger.

Asaad, who formed the FSA in 2011 as a popular uprising against Assad turned into an armed rebellion, was one of the first senior officers to defect from the Syrian military, but was sidelined last year from a new Western-backed FSA command.

Asaad's deputy, Malik al-Kurdi, told Al Jazeera television he believed the Syrian government had tried to assassinate the FSA founder with a bomb planted directly below his car seat. He said Asaad had also suffered face wounds.

No group has claimed responsibility for the attack.

Video footage posted online by activists showed Asaad lying on a bed with a bandage on his head and groaning. He was covered in a blue sheet and a man in the film said he would survive. Reuters could not independently verify the video.

REBEL FORCES DIVIDED

Various rebel units fight under the banner of the FSA, which has struggled to find weapons supplies and build a disciplined command and control structure. It does not include some Islamist militants such as the powerful al Qaeda-linked Nusra Front.

Moaz Alkhatib, who resigned on Sunday as head of the opposition Syrian National Coalition, said the attack on Asaad was part of a drive to "assassinate the free leaders of Syria".

Despite stepping down, Alkhatib said he would address an Arab League summit in Qatar this week. "I have decided to give a speech in the name of the Syrian people at the Doha conference," he wrote on his Twitter account on Monday.

Alkhatib, named leader of the coalition formed in November, is a Sunni Muslim cleric who had been seen as a moderate bulwark against the influence of al Qaeda-linked jihadist forces.

He resigned after the coalition berated him for offering Assad a negotiated deal and after the group went ahead, despite his objections, with steps to form a provisional government that would have diminished his authority.

The coalition is backed by Western powers and many Arab states, but Russia and China are critical of its insistence that Assad quit as a precondition for negotiations.

A senior Russian diplomat said on Monday his country wanted Russian and Chinese experts to take part in a U.N. investigation into charges that chemical arms were used in Syria on March 19.

U.N. Secretary-General Ban Ki-moon announced the inquiry on Thursday and made clear it would focus on a rocket attack that killed 26 people near Aleppo. Syria's government and opponents accused each other of firing a missile laden with chemicals.

Opposition activists said Syrian forces had used phosphorus on Monday when they fired multiple rocket launchers at fighters besieging an army base in Adra, a town near Damascus. Two rebels were killed and 23 wounded. The activists described it as another chemical attack. There was no independent confirmation.

U.S. and European officials say they have no evidence yet of any chemical attack. If one is confirmed, it would be the first use of such weapons by either side in the Syrian conflict.

Damascus has not confirmed it possesses chemical weapons, but says if it had them it would not use them on its own people.

(Additional reporting by Jonathon Burch in Ankara, Khaled Yacoub Oweis in Amman, Steve Gutterman in Moscow and Ari Rabinovitch in Jerusalem; Writing by Alistair Lyon; Editing by Louise Ireland and Pravin Char)

Source: http://news.yahoo.com/rebel-mortar-fire-hits-damascus-army-gunners-retaliate-135238660.html

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Sequencing tracks animal-to-human transmission of bacterial pathogens

Mar. 22, 2013 ? Researchers have used whole genome sequencing to reveal if drug-resistant bacteria are transmitted from animals to humans in two disease outbreaks that occurred on different farms in Denmark. The results, which are published today in EMBO Molecular Medicine, confirm animal-to-human transmission of methicillin-resistant Staphylococcus aureus (MRSA), a disease-causing bacterium that carries the recently described mecC gene. The mecC gene is responsible for resistance to the penicillin-like antibiotic methicillin.

Drug-resistant bacterial infections pose a significant challenge to public health and may have severe and sometimes fatal consequences. As the costs of whole genome sequencing methods continue to plummet and the speed of analysis increases, it becomes increasingly attractive for scientists to use whole genome sequencing to answer disease-related questions.

"We used whole genome sequencing to see if we could determine if the two disease outbreaks were caused by the same bacterium and to investigate if the pathogens were transmitted from animal to humans or the other way around," remarked Mark Holmes, from the University of Cambridge and the senior author on the paper. "At first glance, it seems reasonable to expect the same pathogen to be the source of the two outbreaks at the two geographically close locations. By looking at the single differences in nucleotides or SNPs in the DNA sequences of each isolate, it became obvious that two different strains of bacteria were responsible for the two disease outbreaks. In one case, the results also clearly showed that the most likely direction of transmission was from animal to human."

Methicillin-resistant S. aureus can lead to debilitating skin and soft tissue infections, bacteremia, pneumonia and endocarditis. The researchers used an Illumina HiSeq sequencing system to take a close look at the nucleotide sequence of each pathogen. By comparing single difference in nucleotides in the two sequences (single nucleotide polymorphisms) they were able to reach conclusions about the identity of the pathogens and the routes of infection.

The researchers emphasize that while whole genome sequencing cannot replace other more traditional types of diseases analysis it can greatly increase the ability of scientists to distinguish between different pathogens as the cause of disease.

"Our findings demonstrate that the MRSA strains we studied are capable of transmission between animals and humans, which highlights the role of livestock as a potential reservoir of antibiotic-resistant bacteria," remarked Ewan Harrison, one of the lead authors of the study.

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The above story is reprinted from materials provided by EMBO - excellence in life sciences.

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Journal Reference:

  1. Ewan M. Harrison, Gavin K. Paterson, Matthew T.G. Holden, Jesper Larsen, Marc Stegger, Anders Rhod Larsen, Andreas Petersen, Robert L. Skov, Judit Marta Christensen, Anne Bak Zeuthen, Ole Heltberg, Simon R. Harris, Ruth N. Zadoks, Julian Parkhill, Sharon J. Peacock, Mark A. Holmes. Whole genome sequencing identifies zoonotic transmission of MRSA isolates with the novelmecAhomologuemecC. EMBO Molecular Medicine, 2013; DOI: 10.1002/emmm.201202413

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/0hbveD-BUWY/130325093712.htm

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